Meldrum-Based-1<i>H</i>-1,2,3-Triazoles as Antidiabetic Agents: Synthesis, <i>In Vitro</i> α-Glucosidase Inhibition Activity, Molecular Docking Studies, and <i>In Silico</i> Approach

A series of novel alkyl derivatives (2–5a,b) and 1H-1,2,3-triazole analogues (7a–k) Meldrum’s acid were synthesized in a highly effective way by using “click” chemistry screened for vitro α-glucosidase inhibitory activity to examine their antidiabetic potential. 1H NMR, 13C-NMR, high-resolution electrospray ionization mass spectra (HR-ESI-MS) used analyze each the newly compounds. Interestingly, these compounds demonstrated high moderate potency having an IC50 range 4.63–80.21 μM. Among derivatives, compound 7i showed extraordinary was discovered be several times more potent than parent Meldrum (1) standard drug acarbose. Later, molecular docking performed understand binding mode strength all with target enzyme, which revealed that are well fitted active site α-glucosidase. To further ascertain structure compounds, suitable X-ray single crystals 5a, 7a, 7h developed studied. The current investigation has shown combining moiety is beneficial. Furthermore, this first time aforementioned been reported.